Protein Details: Aquaporin-10
Protein ID
ICDB_Pro_1404
Protein Name
Aquaporin-10
Gene Name
AQP10
Organism
Homo sapiens (Human)
Length
301 amino acids
AlphaFoldDB
AF-Q96PS8-F1-model_v4.pdb
Function
[Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol;especially when the cytosolic pH is acidified. Contributes to adipocyte water and glycerol permeability;and may thereby contribute to the utilization of glycerol derived from phospholipid degradation . May contribute to water transport in the intestine (Probable). [Isoform 2]: Water channel that mediates water transport across cell membranes;but that is not permeable to glycerol.
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Keratomalacia and Otitis Media
Location
Detected in epithelial cells on villi in the ileum;and also in stomach;jejunum;colon;rectum;white adipose tissue and placenta (at protein level) (PubMed:15221416;PubMed:23382902). Expressed in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum (PubMed:11573934;PubMed:12084581). Highest expression in absorptive epithelial cells at the tips of villi in the jejunum (PubMed:11573934;PubMed:12084581). Highest expression in absorptive epithelial cells at the tips of villi in the jejunum (PubMed:11573934;PubMed:12084581). Detected in subcutaneous adipose tissue (PubMed:23382902)
DOI ID
10.1006/bbrc.2001.5661; 10.1016/s0167-4781(02)00393-7; 10.1038/nature04727; 10.1101/gr.2596504; 10.1007/s00418-004-0657-1; 10.1074/jbc.m111.242677; 10.1371/journal.pone.0054474; 10.1038/s41467-018-07176-z
RefSeq
NP_536354.2 [Q96PS8-1]